Are pawpaws neurotoxic?
It sounds like an absurd question to ask. After all, many people eat these wild fruits every year without experiencing any apparent negative effects.
But let’s consider the following pieces of information:
Studies have linked the consumption of fruits in the Annonaceae family to neurodegeneration in humans. Pawpaw (Asimina triloba) is in the Annonaceae family.
A compound isolated from pawpaws is neurotoxic in laboratory studies.
And a case report from 2020 describes a man who developed a possible variant of a neurodegenerative disorder called progressive supranuclear palsy. The man was known to eat lots of pawpaws.
Of course, none of this information is conclusive, but it does make some people wonder. Are pawpaws neurotoxic? Should we avoid eating them? Or is this issue overhyped?
In the following video, I share my thoughts.